{"id":1705,"date":"2026-05-15T10:40:43","date_gmt":"2026-05-15T14:40:43","guid":{"rendered":"https:\/\/umaine.edu\/cobre\/?p=1705"},"modified":"2026-05-15T10:54:49","modified_gmt":"2026-05-15T14:54:49","slug":"new-research-explores-advanced-imaging-in-metastatic-breast-cancer","status":"publish","type":"post","link":"https:\/\/umaine.edu\/cobre\/2026\/05\/15\/new-research-explores-advanced-imaging-in-metastatic-breast-cancer\/","title":{"rendered":"New Research Explores Advanced Imaging in Metastatic Breast Cancer"},"content":{"rendered":"\n

New research from the Tilbury Laboratory highlights how advanced label-free optical imaging techniques can provide deeper insight into collagen remodeling in metastatic breast cancer and its role in tumor progression.<\/p>\n\n\n\n

Using Second Harmonic Generation (SHG) imaging and two-photon microscopy in 3D human breast cancer spheroid models, researchers investigated how breast cancer cells remodel collagen architecture across multiple spatial scales, from fibril-level organization to larger extracellular matrix (ECM) structures. These imaging approaches allowed the team to better visualize cancer-driven collagen remodeling and its potential as a therapeutic target.<\/p>\n\n\n\n

The research also explored how targeting the D93 cryptic collagen epitope with a monoclonal antibody reduced metastatic cell migration, further supporting the growing understanding that extracellular matrix remodeling plays a critical role in cancer invasion and progression.<\/p>\n\n\n\n

This work represents an exciting contribution to the growing field of tumor microenvironment and extracellular matrix imaging research and marks Jordan Miner\u2019s first manuscript developed from dissertation research.<\/p>\n\n\n\n

Contributors to the project include Jordan Miner<\/a>, Andre Khalil<\/a>, Zoe Vittum<\/a>, Chris Emmerling<\/a>, Joseph R.<\/a>, Joshua Hamilton<\/a>, and Peter Brooks<\/a>.<\/p>\n\n\n

\n
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New research from the Tilbury Laboratory highlights how advanced label-free optical imaging techniques can provide deeper insight into collagen remodeling in metastatic breast cancer and its role in tumor progression. Using Second Harmonic Generation (SHG) imaging and two-photon microscopy in 3D human breast cancer spheroid models, researchers investigated how breast cancer cells remodel collagen architecture […]<\/p>\n","protected":false},"author":2564,"featured_media":1706,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11,15],"tags":[],"class_list":["post-1705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research"],"yoast_head":"\nNew Research Explores Advanced Imaging in Metastatic Breast Cancer - Center for Biomedical Research Excellence (COBRE) - 91爆料<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/cobre\/2026\/05\/15\/new-research-explores-advanced-imaging-in-metastatic-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Research Explores Advanced Imaging in Metastatic Breast Cancer - Center for Biomedical Research Excellence (COBRE) - 91爆料\" \/>\n<meta property=\"og:description\" content=\"New research from the Tilbury Laboratory highlights how advanced label-free optical imaging techniques can provide deeper insight into collagen remodeling in metastatic breast cancer and its role in tumor progression. 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