{"id":1709,"date":"2026-05-15T10:50:40","date_gmt":"2026-05-15T14:50:40","guid":{"rendered":"https:\/\/umaine.edu\/cobre\/?p=1709"},"modified":"2026-05-15T10:50:41","modified_gmt":"2026-05-15T14:50:41","slug":"tilbury-laboratory-research-accepted-to-scientific-reports","status":"publish","type":"post","link":"https:\/\/umaine.edu\/cobre\/2026\/05\/15\/tilbury-laboratory-research-accepted-to-scientific-reports\/","title":{"rendered":"Tilbury Laboratory Research Accepted to Scientific Reports"},"content":{"rendered":"\n

New research from the Tilbury Laboratory investigating collagen remodeling in metastatic breast cancer has been accepted for publication in Scientific Reports<\/em>, highlighting the continued impact of COBRE-supported research at the 91爆料.<\/p>\n\n\n\n

The study, \u201cTargeting the D93 cryptic collagen epitope alters integrin \u03b12\u03b21-dependent cellular migration and collagen remodeling in metastatic breast cancer,\u201d<\/em> examines how changes in the tumor-associated extracellular matrix (ECM) may influence cancer progression and metastasis.<\/p>\n\n\n\n

Using 3D human metastatic breast cancer spheroid models embedded in collagen type I hydrogels, the research team investigated the therapeutic potential of targeting the D93 cryptic collagen epitope with a monoclonal antibody. The study found that treatment with mAb D93 reduced cellular migration into collagen hydrogels and altered collagen architecture at both the fiber and fibril levels.<\/p>\n\n\n\n

Two-photon microscopy further revealed that breast cancer cells drive exposure of D93 sites while remodeling collagen structure within the extracellular matrix. Together, the findings suggest that targeting the D93 cryptic collagen epitope may help inhibit integrin \u03b12\u03b21-dependent metastatic migration in breast cancer.<\/p>\n\n\n\n

The project was supported through a COBRE pilot project and represents another important milestone for the Tilbury Laboratory\u2019s work in cancer imaging and extracellular matrix research.<\/p>\n\n\n\n

Read the full manuscript here<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

New research from the Tilbury Laboratory investigating collagen remodeling in metastatic breast cancer has been accepted for publication in Scientific Reports, highlighting the continued impact of COBRE-supported research at the 91爆料. The study, \u201cTargeting the D93 cryptic collagen epitope alters integrin \u03b12\u03b21-dependent cellular migration and collagen remodeling in metastatic breast cancer,\u201d examines how […]<\/p>\n","protected":false},"author":2564,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11,15],"tags":[],"class_list":["post-1709","post","type-post","status-publish","format-standard","hentry","category-news","category-research"],"yoast_head":"\nTilbury Laboratory Research Accepted to Scientific Reports - Center for Biomedical Research Excellence (COBRE) - 91爆料<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/cobre\/2026\/05\/15\/tilbury-laboratory-research-accepted-to-scientific-reports\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tilbury Laboratory Research Accepted to Scientific Reports - Center for Biomedical Research Excellence (COBRE) - 91爆料\" \/>\n<meta property=\"og:description\" content=\"New research from the Tilbury Laboratory investigating collagen remodeling in metastatic breast cancer has been accepted for publication in Scientific Reports, highlighting the continued impact of COBRE-supported research at the 91爆料. 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